Species Profile - Cylindrospermopsis raciborskii

Cylindrospermopsis raciborskii

Common Name: Cylindro

Synonyms and Other Names:

Anabaena raciborskii

Rex Lowe

Identification: This species of cyanobacterium (blue-green alga) is composed of trichomes (chained filaments) that are solitary and straight. In Mona Lake, within the Lake Michigan basin, their tube-shaped cells contain groups of scattered gas vesicles and are divided by barely visible walls (Hong et al. 2006). In other populations, such as in Lake Constance near Ottawa, Ontario, the cell walls are thick and conspicuous (Hamilton et al. 2005). The terminal cells may differentiate into cone-shaped heterocytes. Akinetes (thick-walled spore-like structures) are cylindrical to oval-shaped, found singly or in pairs, near the terminal heterocytes (Hong et al. 2006). Both straight and coiled trichomes of this species exist in different locations around the world. Morphological variation in trichomes, vegetative cells and heterocytes can occur even among very similar genetic isolates of C. raciborskii, depending on abiotic conditions (Saker et al. 1999a, Saker and Neilan 2001, Shafik et al. 2003).

Size: In Mona Lake, trichomes range from 51–311 µm in length and 1.7–4.2 µm in width, heterocytes are 5–11 µm by 2–5 µm, and akinetes are 8–16 µm by 2–5 µm (Hong et al. 2006).

Native Range: The genus Cylindrospermopsis is regarded as tropical/subtropical in origin, but it has expanded into temperate areas, particularly the northern hemisphere. The strain of C. raciborskii introduced to the Great Lakes may have originated in South America.


This map only depicts Great Lakes introductions. Click here for Great Lakes region collection information

Great Lakes Nonindigenous Occurrences: Cylindrospermopsis raciborskii was recorded from Mona Lake in 2002 and 2003 as well as Muskegon Lake in 2005, both of which are in the Lake Michigan basin, Michigan (Hong et al. 2006). There is a single earlier record of this species in Lake Erie from 1971 (Taft and Taft 1971) that may have been previously misidentified as Anabaenopsis raciborskii (Kling 2004). This species was also more recently recorded from Lake Erie (Conroy et al. 2006).

Table 1. Great Lakes region nonindigenous occurrences, the earliest and latest observations in each state/province, and the tally and names of HUCs with observations†. Names and dates are hyperlinked to their relevant specimen records. The list of references for all nonindigenous occurrences of Cylindrospermopsis raciborskii are found here.

State/Province	Year of earliest observation	Year of last observation	Total HUCs with observations†	HUCs with observations†
Michigan	2002	2005	2	Muskegon; Pere Marquette-White
Ohio	1971	1971	1	Lake Erie

Table last updated 5/25/2018

† Populations may not be currently present.

Ecology: Akinetes may persist as spores in the sediments for long periods of time. Akinete formation may be triggered by cold temperatures or large temperature fluctuations, and requires high levels of reactive phosphorus (Moore et al. 2003, Moore et al. 2005). In temperate regions, germination occurs roughly in response to water temperature rising to 22–24°C (Hong et al. 2006, Padisak 2003). Akinetes are probably necessary to stimulate a new season’s growth, providing the initial bloom with concentrated phosphorus. Upon germination, akinetes elongate, split open, and the germling cells that emerge eventually become trichomes (Moore et al. 2004). In tropical or subtropical waters, this species is perennial and akinetes rarely develop (Padisak 2003).

Algae blooms consist of trichomes found in and below the euphotic zone, not at the surface (Saker and Griffiths 2001). Concentrations of this species in Mona and Muskegon Lakes have remained low during late summer sampling, accounting for 6% of phytoplankton count in 2002 and 2003 in the former and < 1% in 2005 in the latter, possibly due to temperature limitations (Hong et al. 2006). This species can reach very high concentrations (e.g., 176 000 units ml-1 in Newnans Lake, Florida) (Chapman and Schelske 1997).

In Constance Lake, Ontario, C. raciborskii blooms appear to be controlled by water temperature and not nutrients (Hamilton et al. 2005). This species is capable of fixing atmospheric nitrogen in its heterocytes in response to low cell nitrogen concentration, as well as taking up phosphorus at low concentrations (Shafik et al. 2001, Sprober et al. 2003). The relatively high phosphorus uptake affinity and storage capacity confer a competitive advantage upon this species both in deep lakes with nutrient stratification as well as in lakes lacking such nutrient gradation (Istvanovics et al. 2000). Moreover, this species may also compete well for light in destratified lakes (Antenucci et al. 2005) and artificially mixed reservoirs (Burford et al. 2006). Conditions that are often associated with blooms of C. raciborskii include: low flow; low water level; low nitrogen to phosphorus ratio; high water temperature; stable thermal stratification; increased retention time; high pH; high sulfate concentration; anoxia in at least some strata; high turbidity; high incident irradiation; and low macrophyte biomass (Berger et al. 2006, Bormans et al. 2004, Bouvy et al. 1999, Bouvy et al. 2006, Bowling 1994, Briand et al. 2002, Chellappa and Costa 2003, Da Silva et al. 2001, Fabbro and Duivenvoorden 1996, Hong et al. 2006, Mayer et al. 1997, McGregor and Fabbro 2000, Ramberg 1987, Saker and Neilan 2001, Tucci and Sant’Anna 2003). The optimum temperature for growth is 25–30°C, although growth can occur between 15°C and 35°C, depending on the strain. The optimum light intensity for growth is 80–121 µmol m^-2 s^-1, but growth occurs at levels as low as 22 µmol m^-2 s^-1 (Briand et al. 2004, Chonudomkul et al. 2004, Saker and Griffiths 2000, Shafik et al. 2001). The maximum salinity tolerance is 4 g L^-1 NaCl (Moisander et al. 2002).

Some strains of this species are capable of producing cylindrospermopsin, a toxic compound that affects the human liver and kidneys, as well as anatoxin-a and saxitoxin, which both act as paralytic shellfish neurotoxins (Schembri et al. 2001). Increased production of cylindrospermopsin is associated with long periods of growth in high light intensity conditions (Dyble et al. 2006), in the presence of a fixed nitrogen source (Saker and Neilan 2001), and at lower water temperatures (Saker and Griffiths 2000).

Means of Introduction: Potential modes of introduction of this species to the Lake Michigan watershed include shipping, recreational boating, waterfowl, and/or wind dispersal (Hong et al. 2006).

Status: Established.

Great Lakes Impacts:

There is little or no evidence to support that Cylindrospermopsis raciborskii has significant environmental impacts in the Great Lakes.

Realized:
Cylindrospermopsis raciborskii is found in relatively low abundances in Lake Erie (16-1,942 trichomes/mL), Muskegon Lake (~42 trichomes/mL), and Bear Lake (~1,000 trichomes/mL) (Conroy et al. 2007, Xie et al. 2011). As a result of these low abundances, many of the negative environmental impacts seen in other locations around the world where there are higher densities are not yet occurring in the Great Lakes basin.

Potential:
Some strains of C. raciborskii produce a variety of toxins including cylindrospermopsin, anatoxin-a, and saxitoxin. These toxins have been responsible for fish kills in a reservoir in Brazil and cattle deaths in Australia (De Souza et al. 1998, Saker et al. 1999b, Thomas et al. 1998). Cylindrospermopsin has been found to bioaccumulate in certain species of mollusks, crayfish, and snails; in some cases this exposure was toxic (Kiss et al. 2002, Saker et al. 2004, Saker and Eagleshame 1999, White et al. 2006, Metcalf et al. 2002). Anatoxin produced by some strains of C. raciborskii has been found to affect snails (Kiss et al. 2002).

At high densities (e.g., > 90% phytoplankton biomass) in more tropical climates, C. raciborskii can cause a reduction in biodiversity. This is because of its ability to fix atmospheric nitrogen, sequester phosphorous, and move throughout the water column (Borics et al. 2000, Bouvy et al. 2001, Dobberfuhl 2003, Leonarda and Paerl 2005). In the St. Johns River System, Florida, C. raciborskii appears to reduce the size and diversity of zooplankton by sequestering nutrients and making them unavailable to grazers in the water column (Leonard and Paerl 2005). Some rotifers and cladocerans exhibit reduced feeding rates, growth rates, or growth potential in the presence of C. raciborskii (Hawkins and Lampert 1989, Nogueira et al. 2004, Rothaupt 1991). C. raciborskii may also cause phytoplankton diversity to decrease, as has been observed in Lake Jesup, Florida (Dobberfuhl 2003) and a pond in Hungary (Borics et al. 2000).

Cylindrospermopsis raciborskii has a moderate socio-economic impact in the Great Lakes.
Realized:
Cylindrospermopsis raciborskii is found in relatively low abundances throughout the Great Lakes and as a result these populations do not yet exhibit the negative socio-economic impacts seen in other locations around the world with larger populations of C. raciborskii.

Potential:
A history of human health and water quality impacts elsewhere in the world under conditions similar to those found in the Great Lakes warrants significant concern, resulting in the assessment of this species as likely to have moderate socioeconomic impact.

Cylindrospermopsin from toxic C. raciborskii strains has caused liver damage and even death in humans, when the species occurs in water supply systems (Bernard et al. 2003; Falconer and Humpage 2006; Hawkins et al. 1985). Cylindrospermopsin also has the potential to be genotoxic or carcinogenic in humans and to cause acute skin reactions in people on contact (Falconer and Humpage 2001; Falconer and Humpage 2006; Humpage et al. 2000; Shen et al. 2002; Stewart et al. 2006).

Strains of C. raciborskii that produce toxins can severely impact water quality both in drinking water for humans and as a result of bioaccumulation in aquatic organisms (Bernard et al. 2003, Bouke et al. 1983, Hawkins et al. 1985, Kiss et al. 2002, Saker et al. 2004, Saker and Eagleshame 1999, White et al. 2006).

Cylindrospermopsin is a potent inhibitor of protein synthesis, an irritant, and causes cutaneous sensitizing that could be harmful to recreational users of impacted water bodies; to date, however, populations in the Great Lakes basin have not been known to produce cylindrospermopsin (Conroy et al. 2007, Stewart et al. 2006, Xie et al. 2011). Treatment of a C. raciborskii bloom with copper sulfate resulted in contamination of a reservoir on Palm Island, Australia with cylindrospermopsin. After drinking the contaminated water, 141 people were hospitalized with hepatoenteritis and other symptoms affecting kidneys, adrenal glands, small intestine, lungs, thymus, and heart (Bernard et al. 2003, Bouke et al. 1983, Hawkins et al. 1985). There is also accumulating evidence that cylindrospermopsin is carcinogenic (Falconer and Humpage 2001).

There are multiple reports of toxic C. raciborskii blooms occurring in aquaculture ponds in Australia and other tropic regions. This often results in bioaccumulation of cylindrospermopsin within the organisms intended for harvest and the economic loss of infected organisms. Such blooms also create a risk of the toxin getting into the human food market if not detected soon enough (Saker and Eaglesham 1999).

Furthermore, in areas outside of the Great Lakes, the overwhelming biomass of C. raciborskii blooms in association with the changes to the biodiversity of the system can negatively impact the natural value of the area (Leonard and Paerl 2005).

There is little or no evidence to support that Cylindrospermopsis raciborskii has significant beneficial effects in the Great Lakes.

Management:

Regulations (pertaining to the Great Lakes region)
There are no known regulations for this species.

Note: Check federal, state/provincial, and local regulations for the most up-to-date information.

Control
Biological
There are no known organisms that can degrade cylindrospermopsin. However, several studies have found that a variety of unidentified bacteria degraded 100% of saxitoxin, another toxin produced by C. raciborskii (Donovan et al. 2008, Ho et al. 2012).

Physical
Cylindrospermopsis raciborskii blooms are often associated with a stratified water column, which is one of the reasons they are so prevalent in shallow water bodies with a long turnover period. A mechanical system can be used to create artificial destratification to increase vertical mixing, introduce oxygen, and reduce internal nutrient loading. The installation of a destratification mechanism was attempted in a reservoir in Australia. While there was a reduction in internal nutrient loading, the increased turbidity of the water yielded a competitive advantage for C. raciborskii, which can move throughout the water column to compete for light (Atenucci et al. 2005).

Cylindrospermopsin can be absorbed by activated carbon with high mesopor capacity, and nanofiltration may be another viable option, but not enough research has been done to be conclusive about the efficacy of either technique. Saxitoxins can be absorbed by activated carbons that have a large fraction of the pores that are smaller than 1 nm (Westrick 2010).

Chemical
Cylindrospermopsin can be inactivated by chlorine, ozone, and hydroxyl radical treatments. Saxitoxin can be inactivated by chlorine (Westrick 2010). However, the use of copper-based algicides may inhibit the degradation of cylindrospermopsin (Smith et al. 2008).

Note: Check state/provincial and local regulations for the most up-to-date information regarding permits for control methods. Follow all label instructions.

Remarks: Climate change may be contributing to the expansion of this species in temperate latitudes (Briand et al. 2004, Hamilton et al. 2005). If water temperatures continue to increase and water levels continue to drop, studies suggest these isolated populations within the Great Lake could become much more prominent (Conroy et al. 2007, Wiedner et al. 2007, Xie et al. 2007).

Genetic similarities exist between strains of C. raciborskii from Australia and Europe, Africa and Australia, and North and South America (Dyble et al. 2002, Gugger et al. 2005). The relatively recent colonization of northerly latitudes in North America, including the Great Lakes, probably involves populations originally from South America (Gugger et al. 2005).

References: (click for full references)

Antenucci, J.P., A. Ghadouani, M.A. Burford, and J.R. Romero. 2005. The long-term effect of artificial destratification on phytoplankton species composition in a subtropical reservoir. Freshwater Biology 50(6):1081-1093.

Berger, C., N. Ba, M. Gugger, M. Bouvy, F. Rusconi, A. Coute, M. Troussellier, and C. Bernard. 2006. Seasonal dynamics and toxicity of Cylindrospermopsis raciborskii in Lake Guiers (Senegal, West Africa). FEMS Microbiology Ecology 57(3):355-366.

Bernard, C., M. Harvey, J.F. Briand, R. Bire, S. Krys, and J.J. Fontaine. 2003. Toxicological comparison of diverse Cylindrospermopsis raciborskii strains: evidence of liver damage caused by French C. raciborskii strain. Environmental Toxicology 18(3):176-186.

Borics, G., I. Grigorszky, S. Szabo, and J. Padisak. 2000. Phytoplankton associations in a small hypertrophic fishpond in East Hungary during a change from bottom-up to top-down control. Hydrobiologia 424(1-3):79-90.

Bormans, M., P.W. Ford, L. Fabbro, and G. Hancock. 2004. Onset and persistence of cyanobacterial blooms in a large impounded tropical river, Australia. Marine and Freshwater Research 55(1):1-15.

Bouvy, M., M. Pagano, and M. Troussellier. 2001. Effects of a cyanobacterial bloom (Cylindrospermopsis raciborskii) on bacteria and zooplankton communities in Ingazeira reservoir (northeast Brazil). Aquatic Microbial Ecology 25:215-227.

Bouvy, M., N. Ba, S. Ka, S. Sane, M. Pagano, and R. Arfi. 2006. Phytoplankton community structure and species assemblage succession in a shallow tropical lake (Lake Guiers, Senegal). Aquatic Microbial Ecology 45(2):147-161.

Bouvy, M., R. Molica, S. De Oliveira, M. Marinho, and B. Beker. 1999. Dynamics of a toxic cyanobacterial bloom (Cylindrospermopsis raciborskii) in a shallow reservoir in the semi-arid region of northeast Brazil. Aquatic Microbial Ecology 20(3):285-297.

Bowling, L. 1994. Occurrence and possible causes of a severe cyanobacterial bloom in Lake Cargelligo, New South Wales. Australian Journal of Marine and Freshwater Research 45(5):737-745.

Briand, J.F., C. Leboulanger, J.F. Humbert, C. Bernard, and P. Dufour. 2004. Cylindrospermopsis raciborskii (Cyanobacteria) invasion at mid-latitudes: selection, wide physiological tolerance, or global warming? Journal of Phycology 40(2):231-238.

Briand, J.F., C. Robillot, C. Quiblier-Lloberas, J.F. Hubert, A. Coute, and C. Bernard. 2002. Environmental context of Cylindrospermopsis raciborskii (Cyanobacteria) blooms in a shallow pond in France. Water Research 36(13):3183-3192.

Burford, M.A., K.L. McNeale, and F.J. McKenzie-Smith. 2006. The role of nitrogen in promoting the toxic cyanophyte Cylindrospermopsis raciborskii in a subtropical water reservoir. Freshwater Biology 51(11):2143-2153.

Chapman, A.D., and C.L. Schelske. 1997. Recent appearance of Cylindrospermopsis (Cyanobacteria) in five hypereutrophic Florida lakes. Journal of Phycology 33:191-195.

Chellappa, N.T., and M.A.M. Costa. 2003. Dominant and co-existing species of Cyanobacteria from a eutrophied reservoir of Rio Grande do Norte State, Brazil. Acta Oecologica 24(suppl. 1):S3-S10.

Chonudomkul, D., W. Yongmanitchal, G. Theeragool, M. Kawachi, F. Kasal, K. Kaya, and M. Watanabe. 2004. Morphology, genetic diversity, temperature tolerance and toxicity of Cylindrospermopsis raciborskii (Nostocales, Cyanobacteria) strains from Thailand and Japan. FEMS Microbiology Ecology 48(3):345-355.

Conroy, J.D., D.D. Kane, E.L. Quinlan, and D.A. Culver. 2006. Seeing is believing – synergy amongst Lake Erie plankton and nutrients, exotic species, and climate change. The Fourth Biennial Conference of the Lake Erie Millennium Network – 28 February 2006.

Conroy, J.D., E.L. Quinlan, D.D. Kane, and D.A. Culver. 2007. Cylindrospermopsis in Lake Erie: Testing its association with other cyanobacterial genera and major limnological parameters. Journal of Great Lakes Research 33: 519-535.

Da Silva, C.A., S. Train, and L.C. Rodrigues. 2001. Structure and dynamics of the phytoplankton community downstream and upstream Corumba reservoir, Caldas Novas, state of Goias, Brazil. Acta Scientiarum Universidade Estadual de Maringa 23(2):283-290.

De Souza, R.C.R., M.C. Carvalho, and A.C. Truzzi. 1998. Cylindrospermopsis raciborskii (Wolosz.) Seenaya and Subba Raju (Cyanophyceae) dominance and a contribution to the knowledge of Rio Pequeno arm, Billings Reservoir, Brazil. Environmental Toxicology and Water Quality 13(1):73-81.

Dobberfuhl, D.R. 2003. Cylindrospermopsis raciborskii in three central Florida lakes: population dynamics, controls and management implications. Lake and Reservoir Management 19(4):341-348.

Donovan, C.J., J.C. Ku, M.A. Quilliam, and T.A. Gill. 2008. Bacterial degradation of paralytic shellfish toxins. Toxicon 52: 91-100.

Dyble, J., H.W. Paerl, and B.A. Neilan. 2002. Genetic characterization of Cylindrospermopsis raciborskii (Cyanobacteria) isolated from diverse geographic origins based on nifH and cpcBA-IGS nucleotide sequence analysis. Applied and Environmental Microbiology 68(5):2567-2571.

Dyble, J., P.A. Tester, and R.W. Litaker. 2006. Effects of light intensity on cylindrospermopsin production in the cyanobacterial HAB species Cylindrospermopsis raciborskii. African Journal of Marine Science 28(2):309-312.

Fabbro, L.D., and L.J. Duivenvoorden. 1996. Profile of a bloom of the cyanobacterium Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju in the Fitzroy River in tropical central Queensland. Marine and Freshwater Research 47:685-694.

Falconer, I.R., and A.R. Humpage. 2001. Preliminary evidence for in vivo tumour initiation by oral administration of extracts of the blue-green alga Cylindrospermopsis raciborskii containing the toxin cylindrospermopsin. Environmental Toxicology 16(2):192-195.

Falconer, I.R., and A.R. Humpage. 2006. Cyanobacterial (blue-green algal) toxins in water supplies: Cylindrospermopsis. Environmental Toxicology 21(4, Sp. Iss. SI):299-304.

Gugger, M., R. Molica, B. Le Berre, P. Dufour, C. Bernard, and J.F. Humbert. 2005. Genetic diversity of Cylindrospermopsis strains (Cyanobacteria) isolated from four continents. Applied and Environmental Microbiology 71(2):1097-1100.

Hamilton, P.B., L.M. Ley, S. Dean and F.R. Pick. 2005. The occurrence of the cyanobacterium Cylindrospermopsis raciborskii in Constance Lake: an exotic cyanoprokaryote new to Canada. Phycologia 44(1):17-25.

Hawkins, P.R., M.T.C. Runnegar, A.R.B. Jackson, and I.R. Falconer. 1985. Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic water supply reservoir. Applied and Environmental Microbiology:1292-1295.

Hawkins, P.R., and W. Lampert. 1989. The effect of Daphnia body size on filtering rate inhibition in the presence of a filamentous cyanobacterium. Limnology and Oceanography 34(6):1084-1089.

Ho, L., E. Sawade, and G. Newcombe. 2012. Biological treatment options for cyanobacteria metabolite removal- A review. Water Research 46: 1536-1548.

Hong, Y., A. Steinman, B. Biddanda, R. Rediske, and G. Fahnenstiel. 2006. Occurrence of the toxin-producing cyanobacterium Cylindrospermopsis raciborskii in Mona and Muskegon Lakes, Michigan. Journal of Great Lakes Research 32:645-652.

Humpage, A.R., M. Fenech, P. Thomas, and I.R. Falconer. 2000. Micronucleus induction and chromosome loss in transformed human white cells indicate clastogenic and aneugenic action of the cyanobacterial toxin, cylindrospermopsin. Mutation Research 472(1-2):155-161.

Istvanovics, V., H.M. Shafik, M. Presing, and S. Juhos. 2000. Growth and phosphate uptake kinetics of the cyanobacterium, Cylindrospermopsis raciborskii (Cyanophyceae) in throughflow cultures. Freshwater Biology 43(2):257-275.

Kiss, T., A. Vehovszky, L. Hiripi, A. Kovacs, and L. Voros. 2002. Membrane effects of toxins isolated from a cyanobacterium, Cylindrospermopsin raciborskii, on identified molluscan neurons. Comparative Biochemistry and Physiology Part C Toxicology and Pharmacology 131C(2):167-176.

Kling, H. J. 2004. Cylindrospermopsis raciborskii (Woloszynska) Seenayya and Subba Raju: a brief historic overview and recent discovery in the Assiniboine River. Algal Taxonomy and Ecology Inc., Winnipeg, Manitoba. Revision Date: 09-10/2004

Leonard, J.A. and H.W. Paerl. 2005. Zooplankton community structure, micro-zooplankton grazing impact, and seston energy content in the St. Johns river system, Florida as influenced by the toxic cyanobacterium Cylindrospermopsis raciborskii. Hydrobiologia 537:89-97.

Mayer, J., M.T. Dokulil, M. Salbrechter, M. Berger, T. Posch, G. Pfister, A.K.T. Kirschner, B. Velimirov, A. Steitz, and T. Ulbricht. 1997. Seasonal successions and trophic relations between phytoplankton, zooplankton, ciliate and bacteria in a hypertrophic shallow lake in Vienna, Austria. Hydrobiologia 342-343(0):165-174.

Metcalf, J.S., K.A. Beattie, S. Birmingham, M.L. Saker, A.K. Torokne, and G.A. Codd. 2002. Toxicity of cylindrospermopsin to the brine shrimp Artemia salina: comparisons with protein synthesis inhibitors and microcystins. Toxicon 40(8):1115-1120.

McGregor, G.B., and L.D. Fabbro. 2000. Dominance of Cylindrospermopsis raciborskii (Nostocales, Cyanoprokaryota) in Queensland tropical and subtropical reservoirs: implications for monitoring and management. Lakes and Reservoirs: Research and Management 5(3):195-205.

Moisander, P.H., E. McClinton, and H.W. Paerl. 2002. Salinity effects on growth, photosynthetic parameters, and nitrogenase activity in estuarine planktonic cyanobacteria. Microbial Ecology 43(4):432-442.

Moore, D., G.B. McGregor, and G. Shaw. 2004. Morphological changes during akinete germination in Cylindrospermopsis raciborskii (Nostocales, Cyanobacteria). Journal of Phycology 40(6):1098-1105.

Moore, D., M. O’Donohue, C. Garnett, C. Critchley, and G. Shaw. 2005. Factors affecting akinete differentiation in Cylindrospermopsis raciborskii (Nostocales, Cyanobacteria). Freshwater Biology 50(2):345-352.

Moore, D., M. O’Donohue, G. Shaw, and C. Critchley. 2003. Potential triggers for akinete differentiation in an Australian strain of the cyanobacterium Cylindrospermopsis raciborskii (AWT 205/1). Hydrobiologia 506-509:175-180.

Nogueira, I.C.G., M.L. Saker, S. Pflugmacher, C. Wiegand, and V.M. Vasconcelos. 2004. Toxicity of the cyanobacterium Cylindrospermopsis raciborskii to Daphnia magna. Environmental Toxicology 19(5):453-459.

Padisak, J. 2003. Estimation of minimum sedimentary inoculum (akinete) pool of Cylindrospermopsis raciborskii: a morphology and life-cycle based method. Hydrobiologia 502:389-394.

Ramberg, L. 1987. Phytoplankton succession in the Sanyati Basin, Lake Kariba. Hydrobiologia 153(3):193-202.

Rothhaupt, K.O. 1991. The influence of toxic and filamentous blue-green algae on feeding and population growth of the rotifer Brachionus rubens. Internationale Revue der Gesamten Hydrobiologie 76(1):67-72.

Saker, M.L., and B.A. Neilan. 2001. Varied diazotrophies, morphologies, and toxicities of genetically similar isolates of Cylindrospermopsis raciborskii (Nostocales, Cyanophyceae) from Northern Australia. Applied and Environmental Microbiology 67(4):1839-1845.

Saker, M.L. ,and D.J. Griffiths. 2000. The effect of temperature on growth and cylindrospermopsin content of seven isolates of Cylindrospermopsis raciborskii (Nostocales, Cyanophyceae) from water bodies in northern Australia. Phycologia 39(4):349-354.

Saker, M.L., and D.J. Griffiths. 2001. Occurrence of blooms of the cyanobacterium Cylindrospermopsis raciborskii (Woloszynska) Seenayya and Subba Raju in a north Queensland domestic water supply. Marine and Freshwater Research 52(6):907-915.

Saker, M.L., and G.K. Eaglesham. 1999. The accumulation of cylindrospermopsin from the cyanobacterium Cylindrospermopsis raciborskii in tissues of the redclaw crayfish Cherax quadricarinatus. Toxicon 37(7):1065-1077.

Saker, M.L., J.S. Metcalf, G.A. Codd, and V.M. Vasconcelos. 2004. Accumulation and depuration of the cyanobacterial toxin cylindrospermopsin in the freshwater mussel Anodonta cygnea. Toxicon 43(2):185-194.

Saker, M.L., B.A. Neilan and D.J. Griffiths. 1999a. Two morphological forms of Cylindrospermopsis raciborskii (Cyanobacteria) isolated from Solomon Dam, Palm Island, Queensland. Journal of Phycology 35(3):599-606.

Saker, M.L., A.D. Thomas, and J.H. Norton. 1999b. Cattle mortality attributed to the toxic cyanobacterium Cylindrospermopsis raciborskii in an outback region of North Queensland. Environmental Toxicology 14(1):179-182.

Schembri, M.A., B.A. Neilan, and C.P. Saint. 2001. Identification of genes implicated in toxin production in the cyanobacterium Cylindrospermopsis raciborskii. Environmental Toxicology 16(5):413-421.

Shafik, H.M., S. Herodek, M. Presing, and L. Voros. 2001. Factors affecting growth and cell composition of cyanoprokaryote Cylindrospermopsis raciborskii (Woloszynska) Seenayya and Subba Raju. Archiv fuer Hydrobiologie, Algological Studies 140(2p.1/4):75-93.

Shafik, H.M., L. Voros, P. Sprober, M. Presing, and A.W. Kovacs. 2003. Some special morphological features of Cylindrospermopsin raciborskii in batch and continuous cultures. Hydrobiologia 506-509:163-167.

Shen, X., P.K.S. Lam, G.R. Shaw, and W. Wickramasinghe. 2002. Genotoxicity investigation of a cyanobacterial toxin, cylindrospermopsin. Toxicon 40(10):1499-1501.

Smith, M.J., G.R. Shaw, G.K. Eaglesham, L. Ho, and J.D. Brookes. 2008. Elucidating the factors influencing the biodegradation of cylindrospermopsin in drinking water sources. Environmental Toxicology 23(3): 413-421.

Sprober, P., H.M. Shafik, M. Presing, A.W. Kovacs, and S.Herodek. 2003. Nitrogen uptake and fixation in the cyanobacterium Cylindrospermopsis raciborskii under different nitrogen conditions. Hydrobiologia 506-50:169-174.

Stewart, I., A.A. Seawright, P.J. Schluter, and G.R. Shaw. 2006. Primary irritant and delayed-contact hypersensitivity reactions to the freshwater cyanobacterium Cylindrospermopsis raciborskii and its associated toxin cylindrospermopsin. Dermatology 6(5):1-12.

Taft, C.E., and C.W. Taft. 1971. Algae of Western Lake Erie. College of Biological Sciences, Ohio State University, Columbus, Ohio.

Thomas, A., M.L. Saker, J.H. Norton, and R.D. Olsen. 1998. Cyanobacterium Cylindrospermopsis raciborskii as a probable cause of death in cattle in northern Queensland. Australian Veterinary Journal 76:592-594.

Tucci, A., and C.L. Sant’Anna. 2003. Cylindrospermopsis raciborskii (Woloszynska) Seenayya and Suba Raju (Cyanobacteria): weekly variation and relation with environmental factors in an eutrophic lake, Sao Paulo, SP, Brazl. Revista Brasileira de Botanica 26(1):97-112.

Westrick, J.A., D.C. Szlang, B.J. Southwell, and J. Sinclair. 2010. A review of cyanobacteria and cyanotoxins removal/ inactivation in drinking water treatment. Analytical and Bioanalytical Chemistry 397(5): 11705-1714.

White, S.H., L.J. Duivenvoorden, L.D. Fabbro and G.K. Eaglesham. 2006. Influence of intracellular toxin concentrations on cylindrospermopsin bioaccumulation in a freshwater gastropod (Melanoides tuberculata). Toxicon 47(5):497-509.

Wiedner, C., J. Ruecker, R. Brueggemann, and B. Nixdorf. 2007. Climate change affects timing and size of populations of an invasive cyanobacterium in temperate regions. Oecologia 152(3): 473-484.

Xie, L., J. Hagar, R.R. Rediske, J. O’Keefe, J. Dyble, Y. Hong, and D. Steinman. 2011. The influence of environmental conditions and hydrologic connectivity on cyanobacteria assemblages in two drowned river mouth lakes. Journal of Great Lakes Research 37: 470-479.

Other Resources:

Great Lakes Waterlife

Author: Kipp, R.M., M. McCarthy, and A. Fusaro

Contributing Agencies:

Revision Date: 9/12/2019

Citation for this information:
Kipp, R.M., M. McCarthy, and A. Fusaro, 2019, Cylindrospermopsis raciborskii: U.S. Geological Survey, Nonindigenous Aquatic Species Database, Gainesville, FL, and NOAA Great Lakes Aquatic Nonindigenous Species Information System, Ann Arbor, MI, https://nas.er.usgs.gov/queries/greatlakes/FactSheet.aspx?SpeciesID=2651&Potential=N&Type=0, Revision Date: 9/12/2019, Access Date: 9/21/2019

This information is preliminary or provisional and is subject to revision. It is being provided to meet the need for timely best science. The information has not received final approval by the U.S. Geological Survey (USGS) and is provided on the condition that neither the USGS nor the U.S. Government shall be held liable for any damages resulting from the authorized or unauthorized use of the information.